EIF2B2 explained

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.^{[1] [2]}

Function

Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.

Interactions

EIF2B2 has been shown to interact with EIF2B5^[3] and NCK1.^[4]

References

Further reading

• Labauge P, Fogli A, Niel F, Rodriguez D, Boespflug-Tanguy O . [CACH/VWM syndrome and leucodystrophies related to EIF2B mutations] . Rev. Neurol. (Paris) . 163 . 8–9 . 793–9 . 2007 . 17878805 . 10.1016/s0035-3787(07)91461-7 .
• Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH . Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease . Nature . 375 . 6534 . 754–760 . 1995 . 7596406 . 10.1038/375754a0 . 1995Natur.375..754S . 4308372 .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–113 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG . T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3 . J. Biol. Chem. . 271 . 19 . 11410–11413 . 1996 . 8626696 . 10.1074/jbc.271.19.11410 . free .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS . Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B . J. Biol. Chem. . 273 . 5 . 3039–3044 . 1998 . 9446619 . 10.1074/jbc.273.5.3039 . free .
• Gomez E, Pavitt GD . Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation . Mol. Cell. Biol. . 20 . 11 . 3965–3976 . 2000 . 10805739 . 85753 . 10.1128/MCB.20.11.3965-3976.2000 .
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS . Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation . Biochim. Biophys. Acta . 1492 . 1 . 56–62 . 2000 . 10858531 . 10.1016/S0167-4781(00)00062-2 .
• Williams DD, Price NT, Loughlin AJ, Proud CG . Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein . J. Biol. Chem. . 276 . 27 . 24697–24703 . 2001 . 11323413 . 10.1074/jbc.M011788200 . free .
• Leegwater PA, Vermeulen G, Könst AA, Naidu S, Mulders J, Visser A, Kersbergen P, Mobach D, Fonds D, van Berkel CG, Lemmers RJ, Frants RR, Oudejans CB, Schutgens RB, Pronk JC, van der Knaap MS . Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter . Nat. Genet. . 29 . 4 . 383–388 . 2001 . 11704758 . 10.1038/ng764 . 20313523 .
• Kebache S, Zuo D, Chevet E, Larose L . Modulation of protein translation by Nck-1 . Proc. Natl. Acad. Sci. U.S.A. . 99 . 8 . 5406–5411 . 2002 . 11959995 . 122782 . 10.1073/pnas.082483399 . 2002PNAS...99.5406K . free .
• Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E . A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation . Neurology . 59 . 12 . 1966–8 . 2003 . 12499492 . 10.1212/01.wnl.0000041666.76863.47 . 13129517 .
• Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O . Ovarian failure related to eukaryotic initiation factor 2B mutations . Am. J. Hum. Genet. . 72 . 6 . 1544–1550 . 2003 . 12707859 . 1180314 . 10.1086/375404 .
• van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC . eIF2B-related disorders: antenatal onset and involvement of multiple organs . Am. J. Hum. Genet. . 73 . 5 . 1199–1207 . 2004 . 14566705 . 1180499 . 10.1086/379524 .
• Richardson JP, Mohammad SS, Pavitt GD . Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity . Mol. Cell. Biol. . 24 . 6 . 2352–2363 . 2004 . 14993275 . 355856 . 10.1128/MCB.24.6.2352-2363.2004 .
• Fogli A, Schiffmann R, Hugendubler L, Combes P, Bertini E, Rodriguez D, Kimball SR, Boespflug-Tanguy O . Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients . Eur. J. Hum. Genet. . 12 . 7 . 561–566 . 2005 . 15054402 . 10.1038/sj.ejhg.5201189 . free .
• Li W, Wang X, Van Der Knaap MS, Proud CG . Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways . Mol. Cell. Biol. . 24 . 8 . 3295–3306 . 2004 . 15060152 . 381664 . 10.1128/MCB.24.8.3295-3306.2004 .

Notes and References

1. Yang W, Hinnebusch AG . Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2 . Mol Cell Biol . 16 . 11 . 6603–16 . December 1996 . 8887689 . 231662 . 10.1128/MCB.16.11.6603.
2. Web site: Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa.
3. Anthony TG, Fabian JR, Kimball SR, Jefferson LS . Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation . Biochim. Biophys. Acta . 1492 . 1 . 56–62 . June 2000 . 10858531 . 10.1016/S0167-4781(00)00062-2 .
4. Kebache S, Zuo D, Chevet E, Larose L . Modulation of protein translation by Nck-1 . . 99 . 8 . 5406–5411 . April 2002 . 11959995 . 122782 . 10.1073/pnas.082483399 . 2002PNAS...99.5406K . free .