EIF2AK4 explained

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.^{[1] [2]}

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM]^[2]

See also

• Gcn2

Further reading

• Nagase T, Kikuno R, Ishikawa KI . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 1 . 65–73 . 2000 . 10718198 . 10.1093/dnares/7.1.65 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Clark AG, Glanowski S, Nielsen R . Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. . Science . 302 . 5652 . 1960–3 . 2003 . 14671302 . 10.1126/science.1088821 . 2003Sci...302.1960C . 6682593 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Barrios-Rodiles M, Brown KR, Ozdamar B . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . etal. free .
• Wissing J, Jänsch L, Nimtz M . Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. . Mol. Cell. Proteomics . 6 . 3 . 537–47 . 2007 . 17192257 . 10.1074/mcp.T600062-MCP200 . etal. free .

Notes and References

1. Berlanga JJ, Santoyo J, De Haro C . Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase . Eur J Biochem . 265 . 2 . 754–62 . Nov 1999 . 10504407 . 10.1046/j.1432-1327.1999.00780.x . free .
2. Web site: Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4.