EDF1 explained

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.^{[1] [2] [3]}

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.

Interactions

EDF1 has been shown to interact with:

• Liver X receptor alpha,
• Peroxisome proliferator-activated receptor gamma,^[4] and
• TATA binding protein.^{[4] [5] [6]}

Further reading

• Li FQ, Ueda H, Hirose S . Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1 . Mol. Cell. Biol. . 14 . 5 . 3013–21 . 1994 . 8164657 . 358669 . 10.1128/mcb.14.5.3013.
• Ozaki J, Takemaru KI, Ikegami T, Mishima M, Ueda H, Hirose S, Kabe Y, Handa H, Shirakawa M . Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1 . Genes Cells . 4 . 7 . 415–24 . 1999 . 10469174 . 10.1046/j.1365-2443.1999.00267.x . 17825943 . free .
• Mariotti M, De Benedictis L, Avon E, Maier JA . Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo . J. Biol. Chem. . 275 . 31 . 24047–51 . 2000 . 10816571 . 10.1074/jbc.M001928200 . free .
• Brendel C, Gelman L, Auwerx J . Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism . Mol. Endocrinol. . 16 . 6 . 1367–77 . 2003 . 12040021 . 10.1210/mend.16.6.0843 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Bolognese F, Pitarque-Martì M, Lo Cicero V, Mantovani R, Maier JA . Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription . Gene . 374 . 87–95 . 2006 . 16567061 . 10.1016/j.gene.2006.01.030 .

Notes and References

1. Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA . EDF-1, a novel gene product down-regulated in human endothelial cell differentiation . J Biol Chem . 273 . 47 . 31119–24 . December 1998 . 9813014 . 10.1074/jbc.273.47.31119 . free .
2. Ballabio E, Mariotti M, De Benedictis L, Maier JA . The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A . Cell Mol Life Sci . 61 . 9 . 1069–74 . April 2004 . 15112053 . 10.1007/s00018-004-4016-0 . 861006 . 11146030 .
3. Web site: Entrez Gene: EDF1 endothelial differentiation-related factor 1.
4. Brendel C, Gelman L, Auwerx J . Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism . Mol. Endocrinol. . 16 . 6 . 1367–77 . June 2002 . 12040021 . 10.1210/mend.16.6.0843 . free .
5. Mariotti M, De Benedictis L, Avon E, Maier JA . Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo . J. Biol. Chem. . 275 . 31 . 24047–51 . August 2000 . 10816571 . 10.1074/jbc.M001928200 . free .
6. Kabe Y, Goto M, Shima D, Imai T, Wada T, ((Morohashi Ki)), Shirakawa M, Hirose S, Handa H . The role of human MBF1 as a transcriptional coactivator . J. Biol. Chem. . 274 . 48 . 34196–202 . November 1999 . 10567391 . 10.1074/jbc.274.48.34196. free .