The Duchy of Joyeuse was created in 1581 by King Henry III of France for his favourite Anne de Joyeuse.
The lordship of Joyeuse, named for the town of Joyeuse, Ardèche, came, in the 13th century, into the possession of the house of Châteauneuf-Randon, and was made into a viscountship in 1432. Guillaume, viscount of Joyeuse, was bishop of Alet, but afterwards left the church, and became a Marshal of France; he died in 1592. Anne de Joyeuse was his eldest son.
Henriette Catherine married twice: first to the vastly wealthy Henri de Bourbon, Duke of Montpensier; then to Charles de Lorraine, Duke of Guise. From her first marriage, she was the maternal grandmother of la Grande Mademoiselle. In 1647, Henriette Catherine gave the duchy to her son Louis de Lorraine.
married Marie Françoise de Valois, duchesse d'Angoulême, daughter of Louis Emmanuel, Duke of Angoulême, who succeeded her father in 1653.
married Élisabeth Marguerite d'Orléans, first cousin of Louis XIV.
Without any heirs, Marie ceded the duchy of Joyeuse to her third cousin once removed Charles François de Lorraine in 1688.
1690–1693 : Louis XIV confiscated the duchy after Charles François entered into the service of Leopold I, Holy Roman Emperor. It was given to Charles François' brother Jean Paul.
He married Armande de La Tour d'Auvergne and had no issue; married Marie Anne de Bourbon secretly and had no issue.
At his death, the title passed to his nephew Charles de Rohan (1715–1787), son of Jules de Rohan, prince de Soubise and Anne Julie de Melun, sister of Louis.