| Term Start: | 10 May 1994 |
| Term End: | 17 January 1995 |
| Primeminister: | Silvio Berlusconi |
| Predecessor: | Livio Paladin |
| Successor: | Enrico Letta |
| Term Start2: | 23 April 1992 |
| Term End2: | 29 May 2001 |
| Birth Date: | 1955 9, df=y |
| Birth Place: | Morozzo, Italy |
| Nationality: | Italian |
| Occupation: | Politician, agronomist |
| Alma Mater: | University of Turin |
Domenico Comino (born 27 September 1955) is an Italian politician, who served as the minister of European affairs and state minister in the mid-1990s.
Comino was born in Morozzo on 27 September 1955.[1] He is one of the former leaders of Lega Nord.[2] He served as state minister for the EU relations in the first cabinet of Silvio Berlusconi in 1994.[3] Comino was one of the five Lega members in the cabinet who resigned from office in December 1994 in order to vote against Berlusconi in the censure motion.[4]
Comino served in the Italian parliament for three successive periods between 1992 and 1997.[1] Until 1999 he was the Lega Nord's president of the Piedmont region.[5] In 1999, he was expelled from Lega Nord and joined an electoral alliance with Forza Italia.[6]