Dishevelled binding antagonist of beta catenin 2 explained

Dishevelled binding antagonist of beta catenin 2 is a protein that in humans is encoded by the DACT2 gene.^[1]

Further reading

• Koga Y, Yao T, Hirahashi M, Kumashiro Y, Ohji Y, Yamada T, Tanaka M, Tsuneyoshi M . Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence . Histopathology . 52 . 5 . 569–77 . 2008 . 18370954 . 10.1111/j.1365-2559.2008.02996.x . 26122361 .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ . Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression . PLOS ONE . 5 . 9 . e12862 . 2010 . 20877624 . 2943476 . 10.1371/journal.pone.0012862 . 2010PLoSO...512862H . free .
• James G. Herman . Jia Y, Yang Y, Brock MV, Zhan Q, Herman JG, Guo M . Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer . J. Pathol. . 230 . 2 . 194–204 . 2013 . 22806826 . 4061565 . 10.1002/path.4073 .
• Cheng H, Lu M, Mao LJ, Wang JQ, Li W, Wen RM, Chen JC . Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas . Asian Pac. J. Cancer Prev. . 13 . 10 . 5069–74 . 2012 . 23244112 . 10.7314/apjcp.2012.13.10.5069. free .
• Zhang X, Yang Y, Liu X, Herman JG, Brock MV, Licchesi JD, Yue W, Pei X, Guo M . Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma . Epigenetics . 8 . 4 . 373–82 . 2013 . 23449122 . 3674046 . 10.4161/epi.24113 .
• Gao S, Yang Z, Zheng ZY, Yao J, Zhang F, Wu LM, Xie HY, Zhou L, Zheng SS . Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing . World J Surg Oncol . 11 . 57 . 2013 . 23496880 . 3605395 . 10.1186/1477-7819-11-57 . free .
• Hou J, Liao LD, Xie YM, Zeng FM, Ji X, Chen B, Li LY, Zhu MX, Yang CX, Qing-Zhao, Chen T, Xu XE, Shen J, Guo MZ, Li EM, Xu LY . DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma . Cancer Prev Res (Phila) . 6 . 8 . 791–800 . 2013 . 23803417 . 10.1158/1940-6207.CAPR-12-0352 . free .
• Wang S, Dong Y, Zhang Y, Wang X, Xu L, Yang S, Li X, Dong H, Xu L, Su L, Ng SS, Chang Z, Sung JJ, Zhang X, Yu J . DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer . Oncogene . 34 . 20 . 2575–85 . 2015 . 25023701 . 4761644 . 10.1038/onc.2014.201 .

Notes and References

1. Web site: Entrez Gene: Dishevelled binding antagonist of beta catenin 2. 2017-09-10.