| Jurisdiction: | Diocese |
| San Luis | |
| Latin: | Dioecesis Sancti Ludovici in Argentina |
| Local: | Diócesis de San Luis |
| Country: | Argentina |
| Metropolitan: | San Juan de Cuyo |
| Province: | San Juan de Cuyo |
| Area Km2: | 76,748 |
| Population: | 385,000 |
| Population As Of: | 2010 |
| Catholics: | 365,000 |
| Catholics Percent: | 94.8 |
| Parishes: | 47 |
| Denomination: | Roman Catholic |
| Rite: | Roman Rite |
| Established: | 20 April 1934 (years ago) |
| Cathedral: | Cathedral of the Immaculate Conception in San Luis |
| Patron: | St Louis IX |
| Bishop: | Gabriel Bernardo Barba |
| Bishop Title: | Bishop |
| Metro Archbishop: | Jorge Eduardo Lozano |
| Emeritus Bishops: | Pedro Daniel Martinez Perea |
The Roman Catholic Diocese of San Luis, is located in the city of San Luis, capital city of San Luis Province in the Cuyo region of Argentina.
On 20 April 1934 Pope Pius XI founded the archdiocese as the Vicariate Apostolic of San Juan de Cuyo from territory taken from the Diocese of San Juan de Cuyo.[1]