| Subdivision Name2: | Vilnius County |
| Settlement Type: | City neighborhood |
| Pushpin Map: | Lithuania |
| Pushpin Map Caption: | Location of Didieji Pupojai |
| Coordinates: | 54.7181°N 25.3919°W |
| Subdivision Type: | Country |
| Subdivision Type2: | County |
| Didieji Pupojai | |
| Subdivision Name3: | Vilnius city municipality |
| Subdivision Type3: | Municipality |
| Population Density Km2: | auto |
| Timezone: | EET |
| Utc Offset: | +2 |
| Timezone Dst: | EEST |
| Utc Offset Dst: | +3 |
Didieji Pupojai is a neighbourhood of Vilnius located in the Antakalnis Eldership. It is situated northeast from the city center and east of Antakalnis. It borders Dvarčionys from the north, Kalnai and Mileišiškės from the southwest, Rokantiškės from the south and Mažieji Pupojai from the southeast.
It is a mostly residential area made up of community gardens and private houses. The area has a small cemetery.