| Depot Creek | |
| Pushpin Map: | Canada Ontario |
| Pushpin Map Caption: | Location of the mouth of Depot Creek in Ontario |
| Subdivision Type1: | Country |
| Subdivision Name1: | Canada |
| Subdivision Type2: | Province |
| Subdivision Name2: | Ontario |
| Subdivision Type3: | Region |
| Subdivision Name3: | Northeastern Ontario |
| Subdivision Type4: | District |
| Subdivision Name4: | Nipissing |
| Source1: | Unnamed lake |
| Source1 Location: | Boulter Township |
| Source1 Coordinates: | 46.1492°N -79.0244°W |
| Source1 Elevation: | 402m (1,319feet) |
| Mouth: | Lake Nosbonsing |
| Mouth Location: | East Ferris |
| Mouth Coordinates: | 46.19°N -79.2086°W |
| Mouth Elevation: | 237m (778feet) |
| River System: | Saint Lawrence River drainage basin |
Depot Creek is a river in Nipissing District in Northeastern Ontario, Canada.[1] It is in the Saint Lawrence River drainage basin and is a tributary of Lake Nosbonsing.
The creek begins at an unnamed lake in geographic Boulter Township[2] and flows southeast to Guilmette Lake, then turns west to Sobie Lake. The river heads northwest into the municipality of Chisholm, continues northwest into the municipality of East Ferris, and reaches its mouth at Lake Nosbonsing. Lake Nosbonsing flows via the Kaibuskong River, the Mattawa River and the Ottawa River to the Saint Lawrence River.