| DeSales High School | |
| Motto: | Faith, Brotherhood, Tradition |
| Address: | 425 Kenwood Drive |
| City: | Louisville |
| State: | Kentucky |
| Zipcode: | 40214 |
| Country: | United States |
| Other Names: | --> |
| Former Names: | --> |
| Type: | Private, college-preparatory school |
| Religious Affiliation: | Roman Catholic |
| Patron: | Francis de Sales |
| Founders: | --> |
| Oversight: | Roman Catholic Archdiocese of Louisville |
| President: | Rick C. Blackwell[1] |
| Teaching Staff: | 23.0 |
| Grades: | 9–12 |
| Gender: | Boys |
| Enrollment: | 326 (2016-2017) |
| Ratio: | 11 |
| Colors: | Brown, Orange, White |
| Nickname: | Colts |
| Accreditations: | --> |
| Affiliations: | --> |
DeSales High School, is a private, Roman Catholic, college-preparatory school for boys in Louisville, Kentucky, United States. It was established in 1956 and is located in the Roman Catholic Archdiocese of Louisville.[2]