David Eisenberg Explained


Birth Date:	15 March 1939
Birth Place:	Chicago, Illinois, US
Fields:	Proteins^[1] Amyloid^[2] Structural biology^[3] ^[4]
Workplaces:	Howard Hughes Medical Institute University of Oxford University of California, Los Angeles Harvard University California Institute of Technology Princeton University
Alma Mater:	Harvard University (undergraduate) The Queen's College, Oxford (postgraduate)
Thesis Title:	Some problems in the electronic structure of molecules
Thesis Url:	http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/dlDisplay.do?docId=oxfaleph019444285
Thesis Year:	1965
Doctoral Advisor:	Charles Coulson
Awards:	Harvey Prize (2008) ISCB Senior Scientist Award (2013)^[5]

David S. Eisenberg (born 15 March 1939) is an American biochemist and biophysicist best known for his contributions to structural biology and computational molecular biology. He has been a professor at the University of California, Los Angeles since the early 1970s and was director of the UCLA-DOE Institute for Genomics & Proteomics, as well as a member of the California NanoSystems Institute (CNSI) at UCLA.^[6] ^[7] ^[8] ^[9]

Education

Eisenberg attended Harvard University and graduated in 1961 with an A.B. in Biochemical Sciences. He went on to the University of Oxford, where he was awarded a D.Phil in 1965^[10] for research supervised by Charles Coulson.

Research

Eisenberg's current research focuses on the structural biology of amyloidogenic proteins, while his computational efforts largely center on the development of bioinformatic/proteomic methodologies for elucidation and analysis of protein interaction networks. His research group hosts the Database of Interacting Proteins.^[11]

Career

Postdoctoral research, Princeton University (1964–1966; with Walter Kauzmann)
Postdoctoral research, California Institute of Technology (1966–1969; with Richard E. Dickerson)
Professor, Department of Chemistry & Biochemistry, UCLA, USA (1969–Present)
Professor, Department of Biological Chemistry, UCLA Medical School
Director, UCLA-DOE Institute for Genomics & Proteomics (1993–2014)
Member, California NanoSystems Institute (CNSI), UCLA
Investigator, Howard Hughes Medical Institute (2001–Present)

Awards

He was the recipient of Harvey Prize (Human Health) 2008 in recognition of his contributions in unfolding the structure of amyloid fibrils. The award was presented to him at a ceremony that took place on March 23, 2009 at the Technion. This recently recognized protein state provides opportunities to understand cells in health and disease.^[12]

1961 - L.J. Henderson Prize
1958-1960 - Harvard College Honorary Scholarships
1961-1964 - Rhodes Scholarship
1972-1977 - USPHS Career Development Award
1975 - UCLA Distinguished Teaching Award
1982 - McCoy Award of the UCLA Department of Chemistry and Biochemistry for innovative research
1989 - Member, National Academy of Sciences (Biophysics & Computational Biology section)^[13]
1992 - Pierce Award of the Immunotoxin Society
1996 - Protein Society Stein & Moore Award
1998 - American Chemical Society Repligen Corporation Award in Chemistry of Biological Processes
2000 - Investigator, Howard Hughes Medical Institute
2000 - Amgen Award of the Protein Society
2001 - Fellow, American Association for the Advancement of Science
2003 - Member, American Philosophical Society^[14]
2004 - UCLA Glenn T. Seaborg Medal^[15]
2005 - Harvard University's Westheimer Medal
2008 - ACS Nobel Laureate Signature Award for Graduate Education in Chemistry (as preceptor, student was Rebecca Anne Nelson)
2013 - ISCB (International Society for Computational Biology) Senior Scientist Award
2020 - Passano Award^[16]

Notes and References

Eisenberg . D. . David Eisenberg. McLachlan . A. D. . 10.1038/319199a0 . Solvation energy in protein folding and binding . Nature . 319 . 6050 . 199–203 . 1986 . 3945310. 1986Natur.319..199E . 21867582 .
Balbirnie . M. . Grothe . R. . Eisenberg . D. S. . 10.1073/pnas.041617698 . An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta -sheet structure for amyloid . Proceedings of the National Academy of Sciences . 98 . 5 . 2375–2380 . 2001 . 11226247 . 30146 . 2001PNAS...98.2375B . free .
Lüthy . R. . Bowie . J. U. . Eisenberg . D. . 10.1038/356083a0 . Assessment of protein models with three-dimensional profiles . Nature . 356 . 6364 . 83–85 . 1992 . 1538787 . 1992Natur.356...83L . 4369151 .
10.1126/science.3133767 . Chapman . M. S. . Suh . S. W. . Curmi . P. M. . Cascio . D. . Smith . W. W. . Eisenberg . D. S. . Tertiary structure of plant RuBisCO: Domains and their contacts . Science . 241 . 4861 . 71–74 . 1988 . 3133767. 1988Sci...241...71C .
Fogg . C. N. . Kovats . D. E. . 10.1371/journal.pcbi.1003116 . International Society for Computational Biology Honors David Eisenberg with 2013 Accomplishment by a Senior Scientist Award . PLOS Computational Biology . 9 . 6 . e1003116 . 2013 . 3681620 . 2013PLSCB...9E3116F . free .
http://www.hhmi.org/research/investigators/eisenberg_bio.html HHMI profile of David Eisenberg
http://www.doe-mbi.ucla.edu/People/Eisenberg/ The Eisenberg research lab at UCLA
http://www.doe-mbi.ucla.edu UCLA-DOE Institute for Genomics & Proteomics
Book: Eisenberg, David . Kauzmann, Walter . The structure and properties of water . Clarendon Press . Oxford . 2005 . 0-19-857026-0 .
PhD . David J.. Eisenberg . Some problems in the electronic structure of molecules . University of Oxford . 1965 . David Eisenberg.
Salwinski . L. . Miller . C. S. . Smith . A. J. . Pettit . F. K. . Bowie . J. U. . Eisenberg . D. . David Eisenberg. The Database of Interacting Proteins: 2004 update . 10.1093/nar/gkh086 . Nucleic Acids Research . 32 . 90001 . D449–D451 . 2004 . 14681454 . 308820 .
https://harveypz.net.technion.ac.il/harvey-prize-laureates/ Harvey Prize Award
Web site: David S. Eisenberg. 2021-09-14. www.nasonline.org.
Web site: APS Member History. 2021-09-14. search.amphilsoc.org.
Web site: UCLA Glenn T. Seaborg Symposium - Previous Recipients . 2024-01-05 . www.seaborg.ucla.edu.
https://www.passanofoundation.org/services Passano Award 2020