| Casca River | |
| Pushpin Map: | Brazil |
| River System: | Roncador River |
| Mouth Location: | Chapada dos Guimarães, MT |
| Mouth Coordinates: | -15.0841°N -55.494°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Casca River (pt|Rio Casca) is a river of the state of Mato Grosso, Brazil. It is a tributary of the Roncador River.
The Casca River runs through the Rio da Casca Ecological Station from south to north.Further north the Casca river is dammed for the Casca Hydroelectric Plant.Still further north it joins the Roncador River in an arm of the Manso Dam.