DTX2 explained

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.^[1]

DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.^[2]

Further reading

• Matsuno K . Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats . Development . 121 . 8 . 2633–44 . 1995 . 7671825 . vanc. Diederich RJ . Go MJ . 3 . Blaumueller . CM . Artavanis-Tsakonas . S . 10.1242/dev.121.8.2633 .
• Kishi N . Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis . Int. J. Dev. Neurosci. . 19 . 1 . 21–35 . 2001 . 11226752 . 10.1016/S0736-5748(00)00071-X . vanc. Tang Z . Maeda Y . 3 . Hirai . Asami . Mo . Rong . Ito . Mikiko . Suzuki . Satoshi . Nakao . Keiko . Kinoshita . Tsutomu . 21859491 .
• Yamamoto N . Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor . J. Biol. Chem. . 276 . 48 . 45031–40 . 2002 . 11564735 . 10.1074/jbc.M105245200 . vanc. Yamamoto S . Inagaki F . 3 . Kawaichi . M . Fukamizu . A . Kishi . N . Matsuno . K . Nakamura . K . Weinmaster . G . free .
• Benzinger A . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . vanc. Muster N . Koch HB . 3 . Yates Jr . 3rd . Hermeking . H . free .
• Hiller M . Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing . Am. J. Hum. Genet. . 78 . 2 . 291–302 . 2007 . 16400609 . 10.1086/500151 . 1380236 . vanc. Huse K . Szafranski K . 3 . Jahn . Niels . Hampe . Jochen . Schreiber . Stefan . Backofen . Rolf . Platzer . Matthias .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . vanc. Hao T . Shaw C . 3 . Patel . Akash J . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .
• Yi Z, Yi T, Wu Z . cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos . DNA Seq. . 17 . 3 . 175–80 . 2007 . 17286044 . 10.1080/10425170600857616 . 26424595 .

Notes and References

1. Web site: Entrez Gene: DTX2 deltex homolog 2 (Drosophila).
2. Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA . The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity . J. Biol. Chem. . 278 . 24 . 21930–7 . 2003 . 12670957 . 10.1074/jbc.M301157200 . free .