DLX1 explained

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.^{[1] [2]}

Function

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Letinic K, Zoncu R, Rakic P . Origin of GABAergic neurons in the human neocortex. . Nature . 417 . 6889 . 645–9 . 2002 . 12050665 . 10.1038/nature00779 . 2002Natur.417..645L . 4349070 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Chiba S, Takeshita K, Imai Y . Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 26 . 15577–82 . 2004 . 14671321 . 10.1073/pnas.2536757100 . 307610 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Zhou QP, Le TN, Qiu X . Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation. . Nucleic Acids Res. . 32 . 3 . 884–92 . 2004 . 14769946 . 10.1093/nar/gkh233 . 373381 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Hamilton SP, Woo JM, Carlson EJ . Analysis of four DLX homeobox genes in autistic probands. . BMC Genet. . 6 . 52 . 2006 . 16266434 . 10.1186/1471-2156-6-52 . 1310613 . etal . free .

Notes and References

1. Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K . Cloning and characterization of two members of the vertebrate Dlx gene family . Proc Natl Acad Sci U S A . 91 . 6 . 2250–4 . Apr 1994 . 7907794 . 43348 . 10.1073/pnas.91.6.2250. 1994PNAS...91.2250S . etal. free .
2. Web site: Entrez Gene: DLX1 distal-less homeobox 1 .