CLEC4A explained

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.^{[1] [2]}

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response.

Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[2]

Further reading

• Drickamer K . C-type lectin-like domains. . Curr. Opin. Struct. Biol. . 9 . 5 . 585–90 . 1999 . 10508765 . 10.1016/S0959-440X(99)00009-3 .
• Huang X, Yuan Z, Chen G . Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. . Biochem. Biophys. Res. Commun. . 281 . 1 . 131–40 . 2001 . 11178971 . 10.1006/bbrc.2001.4322 . etal.
• Richard M, Veilleux P, Rouleau M . The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. . J. Leukoc. Biol. . 71 . 5 . 871–80 . 2002 . 10.1189/jlb.71.5.871 . 11994513 . 36809172 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ebner S, Sharon N, Ben-Tal N . Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. . Proteins . 53 . 1 . 44–55 . 2003 . 12945048 . 10.1002/prot.10440 . 30955198 .
• Richard M, Thibault N, Veilleux P . The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents. . Biochem. Biophys. Res. Commun. . 310 . 3 . 767–73 . 2003 . 14550269 . 10.1016/j.bbrc.2003.09.077 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Richard M, Thibault N, Veilleux P . Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2. . Mol. Immunol. . 43 . 10 . 1716–21 . 2006 . 16360206 . 10.1016/j.molimm.2005.10.006 . etal.
• Lorentzen JC, Flornes L, Eklöw C . Association of arthritis with a gene complex encoding C-type lectin-like receptors. . Arthritis Rheum. . 56 . 8 . 2620–32 . 2007 . 17665455 . 10.1002/art.22813 . etal.

Notes and References

1. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S . APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif . J Immunol . 163 . 4 . 1973–83 . Sep 1999 . 10.4049/jimmunol.163.4.1973 . 10438934 .
2. Web site: Entrez Gene: CLEC4A C-type lectin domain family 4, member A.