DBC1 explained

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.^{[1] [2] [3] [4] [5]}

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

Further reading

• Auffray C, Behar G, Bois F . [IMAGE: molecular integration of the analysis of the human genome and its expression] . Comptes Rendus de l'Académie des Sciences, Série III . 318 . 2 . 263–72 . 1995 . 7757816 . etal.
• Habuchi T, Luscombe M, Elder PA, Knowles MA . Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. . Genomics . 48 . 3 . 277–88 . 1998 . 9545632 . 10.1006/geno.1997.5165 .
• Nishiyama H, Takahashi T, Kakehi Y . Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer. . Genes Chromosomes Cancer . 26 . 2 . 171–5 . 2000 . 10469456 . 10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B . 29396978 . etal.
• Nishiyama H, Gill JH, Pitt E . Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. . Oncogene . 20 . 23 . 2956–64 . 2001 . 11420708 . 10.1038/sj.onc.1204432 . 3374427 . etal. free .
• Wright KO, Messing EM, Reeder JE . Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. . J. Urol. . 168 . 6 . 2645–9 . 2002 . 12442002 . 10.1016/s0022-5347(05)64236-x.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Wright KO, Messing EM, Reeder JE . DBCCR1 mediates death in cultured bladder tumor cells. . Oncogene . 23 . 1 . 82–90 . 2004 . 14712213 . 10.1038/sj.onc.1206642 . 3620390 . free .
• Humphray SJ, Oliver K, Hunt AR . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Beetz C, Brodoehl S, Patt S . Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. . Oncol. Rep. . 13 . 2 . 335–40 . 2005 . 15643521 . 10.3892/or.13.2.335. etal. 1 November 2024 .
• Izumi H, Inoue J, Yokoi S . Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. . Hum. Mol. Genet. . 14 . 8 . 997–1007 . 2005 . 15746151 . 10.1093/hmg/ddi092 . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Louhelainen JP, Hurst CD, Pitt E . DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. . Oncogene . 25 . 16 . 2409–19 . 2006 . 16369496 . 10.1038/sj.onc.1209228 . 3349365 . etal. free .

Notes and References

1. Habuchi T, Yoshida O, Knowles MA . A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC . Hum Mol Genet . 6 . 6 . 913–9 . Jul 1997 . 9175739 . 10.1093/hmg/6.6.913 . free .
2. Nishiyama H, Hornigold N, Davies AM, Knowles MA . A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 . Genomics . 59 . 3 . 335–8 . Nov 1999 . 10444335 . 10.1006/geno.1999.5891 .
3. Web site: Entrez Gene: DBC1 deleted in bladder cancer 1.
4. Habuchi T, Yoshida O, Knowles MA . A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC . Hum. Mol. Genet. . 6 . 6 . 913–9 . June 1997 . 9175739 . 10.1093/hmg/6.6.913 . free .
5. Nishiyama H, Hornigold N, Davies AM, Knowles MA . A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 . Genomics . 59 . 3 . 335–8 . August 1999 . 10444335 . 10.1006/geno.1999.5891 .