DAPK3 explained

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.^{[1] [2]}

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.^[3]

Interactions

DAPK3 has been shown to interact with PAWR^[4] and Death associated protein 6.^[4]

Further reading

• Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T . Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization . Journal of Human Genetics . 43 . 3 . 209–11 . 1998 . 9747039 . 10.1007/s100380050073 . free .
• Murata-Hori M, Suizu F, Iwasaki T, Kikuchi A, Hosoya H . ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells . FEBS Letters . 451 . 1 . 81–4 . May 1999 . 10356987 . 10.1016/S0014-5793(99)00550-5 . 43329315 . free .
• Page G, Lödige I, Kögel D, Scheidtmann KH . AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis . FEBS Letters . 462 . 1–2 . 187–91 . Nov 1999 . 10580117 . 10.1016/S0014-5793(99)01529-X . 6061613 . free .
• Page G, Kögel D, Rangnekar V, Scheidtmann KH . Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis . Oncogene . 18 . 51 . 7265–73 . Dec 1999 . 10602480 . 10.1038/sj.onc.1203170 . free .
• Cariou B, Perdereau D, Cailliau K, Browaeys-Poly E, Béréziat V, Vasseur-Cognet M, Girard J, Burnol AF . The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta . Molecular and Cellular Biology . 22 . 20 . 6959–70 . Oct 2002 . 12242277 . 139806 . 10.1128/MCB.22.20.6959-6970.2002 .
• Preuss U, Landsberg G, Scheidtmann KH . Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase . Nucleic Acids Research . 31 . 3 . 878–85 . Feb 2003 . 12560483 . 149197 . 10.1093/nar/gkg176 .
• Kawai T, Akira S, Reed JC . ZIP kinase triggers apoptosis from nuclear PML oncogenic domains . Molecular and Cellular Biology . 23 . 17 . 6174–86 . Sep 2003 . 12917339 . 180930 . 10.1128/MCB.23.17.6174-6186.2003 .
• Burch LR, Scott M, Pohler E, Meek D, Hupp T . Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1 . Journal of Molecular Biology . 337 . 1 . 115–28 . Mar 2004 . 15001356 . 10.1016/j.jmb.2003.10.081 .
• Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME . Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase . The Journal of Biological Chemistry . 279 . 40 . 42055–61 . Oct 2004 . 15292222 . 10.1074/jbc.M403676200 . free .
• Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW . Novel interaction partners of the TPR/MET tyrosine kinase . FASEB Journal . 19 . 2 . 267–9 . Feb 2005 . 15546961 . 10.1096/fj.04-1558fje . free . 17142907 .
• Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L . TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3 . International Journal of Andrology . 28 . 3 . 163–70 . Jun 2005 . 15910542 . 10.1111/j.1365-2605.2005.00522.x . free .
• Shoval Y, Pietrokovski S, Kimchi A . ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene . PLOS Genetics . 3 . 10 . 1884–93 . Oct 2007 . 17953487 . 2041995 . 10.1371/journal.pgen.0030180 . free .
• Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M . Novel ZIP kinase isoform lacks leucine zipper . Archives of Biochemistry and Biophysics . 456 . 2 . 194–203 . Dec 2006 . 17126281 . 2758612 . 10.1016/j.abb.2006.09.026 .

Notes and References

1. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S . ZIP kinase, a novel serine/threonine kinase which mediates apoptosis . Molecular and Cellular Biology . 18 . 3 . 1642–51 . Mar 1998 . 9488481 . 108879 . 10.1128/mcb.18.3.1642.
2. Web site: Entrez Gene: DAPK3 death-associated protein kinase 3.
3. Shoval Y, Pietrokovski S, Kimchi A . ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene . PLOS Genetics . 3 . 10 . 1884–93 . Oct 2007 . 17953487 . 2041995 . 10.1371/journal.pgen.0030180 . free .
4. Kawai T, Akira S, Reed JC . ZIP kinase triggers apoptosis from nuclear PML oncogenic domains . Molecular and Cellular Biology . 23 . 17 . 6174–86 . Sep 2003 . 12917339 . 180930 . 10.1128/MCB.23.17.6174-6186.2003 .