| Official Name: | Cross Keys, Pennsylvania |
| Settlement Type: | Census-designated place |
| Pushpin Map: | Pennsylvania#USA |
| Pushpin Label: | Cross Keys |
| Pushpin Label Position: | top |
| Coordinates: | 40.4458°N -78.4294°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Pennsylvania |
| Subdivision Type2: | County |
| Subdivision Name2: | Blair |
| Subdivision Type3: | Township |
| Subdivision Name3: | Allegheny |
| Unit Pref: | Imperial |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 0.26 |
| Area Land Sq Mi: | 0.26 |
| Area Water Sq Mi: | 0.00 |
| Area Total Km2: | 0.68 |
| Area Land Km2: | 0.68 |
| Area Water Km2: | 0.00 |
| Population Total: | 435 |
| Population As Of: | 2020 |
| Population Density Sq Mi: | 1653.99 |
| Population Density Km2: | 639.75 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 1011 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 16635 (Duncansville) |
| Area Code: | 814/582 |
| Blank Name: | FIPS code |
| Blank Info: | 42-17368 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2805481 |
Cross Keys is an unincorporated community and census-designated place (CDP) in Blair County, Pennsylvania, United States. It was first listed as a CDP prior to the 2020 census.
The CDP is in western Blair County, in the eastern part of Allegheny Township. It is bordered to the west by U.S. Route 22/Pennsylvania Route 764, to the south by the US-22/Interstate 99 interchange, and to the east by the Altoona–Hollidaysburg line of the Norfolk Southern Railway. Altoona is 6miles to the north, Duncansville is 2miles to the south, and Hollidaysburg is 3miles to the southeast.
Cross Keys is in the valley of Beaverdam Branch, which flows southeastward to join the Frankstown Branch of the Juniata River east of Hollidaysburg.