Coumarinolignoid Explained

Coumarinolignoids are a class of phenolic compounds. They are a subset of lignans in which one of the two phenylpropanoids is found in the form of a coumarin.

Examples

• 2-(4-hydroxy-3,5-dimethoxyphenyl)-3-hydroxymethyl-2,3-dihydro-1,4,5-trioxaphenanthren-6-one can be found on Paullinia pinnata
• 5'-hydroxycleomiscosin B, found in Eurycorymbus cavaleriei^[1]
• 5-Methoxypropacin found in Protium unifoliolatum^[2]
• Moluccanin, found in Aleurites moluccanus,^[3] synthesised by Kim et al in 2023.^[4]
• Aleuritin, found in Aleurites fordii^[5]
• Durantin A and repenins, isolated from Duranta

Notes and References

1. 10.1016/j.fitote.2009.04.003. Three lignans and one coumarinolignoid with quinone reductase activity from Eurycorymbus cavaleriei. 2009. Ma. Zhongjun. Zhang. Xiaoyu. Cheng. Lin. Zhang. Peng. Fitoterapia. 80. 6. 320–6. 19376206.
2. 16286307. 2006. Magalhães. A. Zoghbi. MD. Siani. AC. 5-Methoxypropacin, a novel coumarinolignoid from Protium unifoliolatum. 20. 1. 43–6. 10.1080/14786410500055555. Natural Product Research. 38930950.
3. 10.1016/0031-9422(88)80480-1. Moluccanin, a coumarinolignoid from Aleurites moluccana. 1988. Shamsuddin. T.. Rahman. W.. Khan. Suroor A.. Shamsuddin. K.M.. Kintzinger. J.. Phytochemistry. 27. 6. 1908.
4. Kim . Irene Jeongin . Pilkington . Lisa I. . Barker . David . 2023-05-05 . Total Synthesis of Linear Coumarniolignoids (+) and (−)-Sapiumin C, (−)-Moluccanin, and (−)-Hemidesminine . The Journal of Organic Chemistry . en . 88 . 9 . 5900–5912 . 10.1021/acs.joc.3c00292 . 37071826 . 258214382 . 0022-3263. 2292/64128 . free .
5. 10.1016/S0031-9422(00)98005-1. Aleuritin, a coumarinolignoid, and a coumarin from Aleurites fordii. 1989. Fozdar. B.I.. Khan. Suroor A.. Shamsuddin. T.. Shamsuddin. K.M.. Kintzinger. J.. Phytochemistry. 28. 9. 2459.