| Tourney Name: | Copa Libertadores de América |
| Year: | 1980 |
| Dates: | February 16 – August 6 |
| Num Teams: | 21 |
| Associations: | 10 |
| Champion Other: | Nacional |
| Count: | 2 |
| Second Other: |  Internacional |
| Matches: | 75 |
| Goals: | 160 |
| Prevseason: | 1979 |
| Nextseason: | 1981 |
The Copa Libertadores 1980 was the 21st edition of the Copa Libertadores, CONMEBOL's annual international club tournament. Nacional of Uruguay won the competition defeating Brazilian club Internacional. Defending champion Olimpia were eliminated in the semifinals.
| Country | Team | Qualify method |
|---|---|---|
| CONMEBOL (1 berth) | Olimpia | 1979 Copa Libertadores champion |
2 berths | River Plate | 1979 Campeonato Metropolitano champions 1979 Campeonato Nacional champions |
| Vélez Sarsfield | 1979 Copa Libertadores Play-off winner | |
2 berths | 1979 Primera División champion | |
| The Strongest | 1979 Primera División runner-up | |
2 berths | Internacional | 1979 Campeonato Brasileiro Série A champion |
| Vasco da Gama | 1979 Campeonato Brasileiro Série A 2nd place | |
2 berths | Colo-Colo | 1979 Primera División champion |
| O'Higgins | 1979 Liguilla Pre-Copa Libertadores winner | |
2 berths | América de Cali | 1979 Campeonato Profesional champion |
| Santa Fe | 1979 Campeonato Profesional runner-up | |
2 berths | Emelec | 1979 Campeonato Ecuatoriano de Fútbol Serie A champion |
| Universidad Católica | 1979 Campeonato Ecuatoriano de Fútbol Serie A runner-up | |
2 berths | Sol de América | 1979 Primera División runner-up |
| Cerro Porteño | 1979 Primera División third place | |
2 berths | Sporting Cristal | 1979 Torneo Descentralizado champion |
| Atlético Chalaco | 1979 Torneo Descentralizado runner-up | |
2 berths | 1979 Liguilla Pre-Libertadores winner | |
| Nacional | 1979 Liguilla Pre-Libertadores runner-up | |
2 berths | Deportivo Táchira | 1979 Primera División champion |
| Deportivo Galicia | 1979 Primera División runner-up | |
The champions and runners-up of each football association were drawn into the same group along with another football association's participating teams. Three clubs from Paraguay competed as Olimpia was champion of the 1979 Copa Libertadores. They entered the tournament in the Semifinals.
Play OffVélez Sársfield 1-1 a.e.t. River PlateVélez Sarsfield qualify on better goal difference in group
See main article: 1980 Copa Libertadores Finals.
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