| Team1: | Colo-Colo |
| Team2: | Cobreloa |
| City Or Region: | Chile |
| Other Names: | Derby Albo–Loíno |
| First Contested: | 1978 Campeonato Nacional |
| Teams Involved: | Colo-Colo, Cobreloa |
| Mostrecent: | 2014 Apertura |
| Total: | 95 |
| Series: | Official: |
| Largestvictory: | |
| Broadcasters: | CDF |
The Colo Colo–Cobreloa rivalry is a footballing rivalry between Chilean clubs Colo-Colo and Cobreloa. It is considered to be one of the biggest rivalry matches in Chile.