| Colón Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of Colón in Argentina |
| Coordinates: | -32.2242°N -58.1444°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Entre Ríos |
| Seat Type: | Head town |
| Seat: | Colón |
| Unit Pref: | Metric |
| Population Total: | 52718 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
The Colón Department (in Spanish, Departamento Colón) is an administrative subdivision (departamento) of the province of Entre Ríos, Argentina. It is located in the center-east of the province, beside the Uruguay River.
The department has 52,718 inhabitants as per the . The head town is Colón (population 21,000). Other cities and towns are San José, Ubajay, Villa Elisa, Pueblo Liebig, La Clarita, Arroyo Barú, Pueblo Cazes, Hocker and Hambis.