Cobalt-precorrin-5B (C1)-methyltransferase explained

Cobalt-precorrin-5B (C¹)-methyltransferase, cobalt-precorrin-6A synthase, CbiD (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:cobalt-precorrin-5B (C¹)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

cobalt-precorrin-6A + S-adenosyl-L-homocysteine

This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic pathway^[3] of adenosylcobalamin biosynthesis in bacteria such as Salmonella typhimurium, Bacillus megaterium, and Propionibacterium freudenreichii subsp. shermanii.

See also

• Cobalamin biosynthesis

Notes and References

1. Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ . The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway . The Journal of Biological Chemistry . 275 . 51 . 40316–23 . December 2000 . 11007789 . 10.1074/jbc.M007146200 . free .
2. Roessner CA, Williams HJ, Scott AI . Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin . The Journal of Biological Chemistry . 280 . 17 . 16748–53 . April 2005 . 15741157 . 10.1074/jbc.M501805200 . free .
3. Web site: Pathway: adenosylcobalamin biosynthesis I (anaerobic) . R. Caspi . MetaCyc Metabolic Pathway Database . 2013-09-25 . 2020-04-24 .