| Charles P. Henderson | |
| Office: | Mayor of Youngstown, Ohio |
| Term Start: | 1948 |
| Term End: | 1954 |
| Predecessor: | Ralph W. O'Neill |
| Successor: | Frank X. Kryzan |
| Birth Date: | 3 March 1911 |
| Birth Place: | Youngstown, Ohio, U.S. |
| Death Place: | New York City, U.S. |
| Death Cause: | Heart attack |
| Resting Place: | Belmont Park Cemetery, Liberty Township, Trumbull County, Ohio, U.S. |
| Party: | Republican |
| Spouse: | Margaret S. Arms |
| Profession: | Politician |
| Allegiance: | United States |
| Branch: | United States Army |
| Battles: | World War II |
Charles P. Henderson (March 3, 1911 – September 15, 1990)[1] was a Republican Ohio politician who served as mayor of Youngstown, Ohio from 1948 to 54. In 1953, he was appointed by President Dwight D. Eisenhower as a member of the Commission on Intergovernmental Relations.[2]