| Chang Ming-che | |
| Native Name Lang: | zh-tw |
| Office: | President of National Tsinghua University |
| Term Start: | 1975 |
| Term End: | 1981 |
| Predecessor: | Shu Shien-Siu |
| Successor: | Mao Kao-wen |
| Office1: | Minister of National Science Council of the Republic of China |
| Term Start1: | March 1981 |
| Term End1: | 31 May 1984 |
| Predecessor1: | Shu Shien-Siu |
| Successor1: | Chen Li-an |
| Birth Date: | 6 May 1914 |
| Birth Place: | Hanchuan, Heibei |
| Death Place: | United States |
| Alma Mater: | Massachusetts Institute of Technology |
Chang Ming-che (; 6 May 1914 – 31 July 1998) was a Taiwanese academic.[1]