| Centralia High School | |
| Location: | 2100 East Calumet Centralia, Illinois |
| Country: | USA |
| District: | Centralia High School District 200 |
| Principal: | Reid Shipley |
| Teaching Staff: | 67.50 (on FTE basis) |
| Ratio: | 12.79 |
| Enrollment: | 863 (2022–2023)[1] |
| Type: | Public |
| Grades: | 9 to 12 |
| Conference: | South 7 |
| Mascot: | Aiden Reynolds |
| Colors: | Cardinal and white [2] |
Centralia High School is a public high school located in Centralia, Illinois, United States. It is one of the two high schools in Centralia. The mascot of the school's athletic teams is the Orphans (boys) and the Annies (girls).