Cbl TKB domain explained

In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. This N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues.^{[1] [2]}

Notes and References

1. Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ . Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase . Nature . 398 . 6722 . 84–90 . March 1999 . 10078535 . 10.1038/18050 .
2. Langenick J, Araki T, Yamada Y, Williams JG . A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling . Journal of Cell Science . 121 . Pt 21 . 3524–30 . November 2008 . 18840649 . 10.1242/jcs.036798 .