| Cayos Zapatilla | |
| Map: | Central America |
| Coordinates: | 9.25°N -84°W |
| Archipelago: | Bocas del Toro Archipelago |
| Total Islands: | 2 |
| Major Islands: | Cayo Zapatilla Mayor |
| Area Footnotes: | 14 & 34 ha. |
| Elevation M: | 0 |
| Country: | Panama |
| Country Admin Divisions Title: | Province |
| Country Admin Divisions: | Bocas del Toro |
| Country Admin Divisions Title 1: | District |
| Country Admin Divisions 1: | Bocas del Toro |
Cayos Zapatilla (Zapatilla Cayes) is a group of two uninhabited islands located east of Isla Bastimentos in the Bocas del Toro Archipelago of Bocas del Toro Province, Panama. North Cayo Zapatilla is 14 hectares long while south Cayo Zapatilla is comparatively bigger with 34 hectares.[1] Both islands lie within the boundaries of the Isla Bastimentos National Marine Park.