Cannabidiphorol Explained
Cannabidiphorol, the heptyl-homologue of cannabidiol was identified as a natural phytocannabinoid and named cannabidiphorol (CBDP) in 2019.[1] It had previously been reported as a synthetic compound,[2] but was not identified as a natural product prior to 2019. Recently, CBDP has been gained popularity due to it being synthesized and available on a commercial level.[3]
Pharmacology
Pharmacodynamics
CBDP shows weak antagonism at both cannabinoid receptors (CB1 and CB2), similar to cannabidiol (CBD). CBD, however, exhibits stronger antagonism at CB2, reaching a 33% maximum response of SR144528 versus CBDP's 23%.[4]
Both cannabinoids act as weak agonists at the serotonin 5-HT1A receptor, contributing to potential anxiolytic effects.
Unlike CBD, CBDP shows no sign of dopamine D2 receptor agonism.
Unexpectedly, CBDP acts as a positive allosteric modulator (PAM) at the MOR, enhancing met-enkephalin signaling by 37%, potentially affecting pain perception.
See also
Notes and References
- Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G . A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol . Scientific Reports . 9 . 1 . 20335 . December 2019 . 31889124 . 6937300 . 10.1038/s41598-019-56785-1 . 2019NatSR...920335C . free .
- Angiogenic resorcinol derivatives . US . 2012/172339 . Makriyannis A, Nikas SP, Alapafuja SO . 5 July 2012 . Northeastern University Boston . Abondoned . . .
- Web site: Heredia M . 27 May 2024 . What Is CBDP? Everything You Need To Know . 2024-09-13 . herb.co . en.
- Haghdoost M, et al. . CBD Versus CBDP: Comparing In Vitro Receptor-Binding Activities . International Journal of Molecular Sciences . 25 . 14 . 7724 . July 2024 . 39062976 . 11277192 . 10.3390/ijms25147724 . free .
