| Caldera River | |
| Map: | Caldera River map.png |
| Subdivision Type1: | Country |
| Subdivision Name1: | Panama |
| Source1: | Volcán Barú |
| Source1 Location: | Chiriqui Province, Panama |
| Source1 Coordinates: | 8.8485°N -82.4875°W |
| Mouth: | Chiriqui Nuevo River |
| Mouth Coordinates: | 8.6194°N -82.3564°W |
The Caldera River (es|Rio Caldera) is a river of Panama. It passes through the town of Boquete and flows through the Volcán Barú National Park in Chiriqui. It flooded its banks in November 2008. It caused extensive damage to infrastructure and many roads had to be repaired.