CYB5R4 explained

Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.^{[1] [2]}

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM]^[2]

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Zhu H, Larade K, Jackson TA . NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. . J. Biol. Chem. . 279 . 29 . 30316–25 . 2004 . 15131110 . 10.1074/jbc.M402664200 . 3045664 . etal. free .
• Wiemann S, Arlt D, Huber W . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Andersen G, Wegner L, Rose CS . Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus . Diabetes . 53 . 11 . 2992–7 . 2005 . 15504981 . 10.2337/diabetes.53.11.2992 . 3044473 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.

Notes and References

1. Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF . Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells . Proc Natl Acad Sci U S A . 96 . 26 . 14742–7 . Jan 2000 . 10611283 . 24718 . 10.1073/pnas.96.26.14742 . free . 1999PNAS...9614742Z .
2. Web site: Entrez Gene: CYB5R4 cytochrome b5 reductase 4.