CUGBP Elav-like family member 4 explained

CUGBP Elav-like family member 4 (CELF4) also known as bruno-like protein 4 (BRUNOL4) is a protein that in humans is encoded by the CELF4 gene.^{[1] [2]}

Function

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.

Further reading

• Szafranski K, Schindler S, Taudien S . Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. . Genome Biol. . 8 . 8 . R154 . 2008 . 17672918 . 10.1186/gb-2007-8-8-r154 . 2374985 . etal . free .
• Han J, Cooper TA . Identification of CELF splicing activation and repression domains in vivo. . Nucleic Acids Res. . 33 . 9 . 2769–80 . 2005 . 15894795 . 10.1093/nar/gki561 . 1126903 .
• Singh G, Charlet-B N, Han J, Cooper TA . ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. . Nucleic Acids Res. . 32 . 3 . 1232–41 . 2004 . 14973222 . 10.1093/nar/gkh275 . 373409 .
• Tchernev VT, Mansfield TA, Giot L . The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. . Mol. Med. . 8 . 1 . 56–64 . 2002 . 11984006 . 10.1007/bf03402003. 2039936 . etal.
• Ladd AN, Charlet N, Cooper TA . The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. . Mol. Cell. Biol. . 21 . 4 . 1285–96 . 2001 . 11158314 . 10.1128/MCB.21.4.1285-1296.2001 . 99581 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Good PJ, Chen Q, Warner SJ, Herring DC . A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator . J Biol Chem . 275 . 37 . 28583–92 . Oct 2000 . 10893231 . 10.1074/jbc.M003083200 . free .
2. Web site: Entrez Gene: BRUNOL4 bruno-like 4, RNA binding protein (Drosophila).