CRTC1 explained

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1, is a protein that in humans is encoded by the CRTC1 gene.^{[1] [2] [3] [4]} It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands^[5] and various regions of the adult central nervous system.^[6]

Clinical significance

Production of CRTC1 is blocked in Alzheimer's disease.^[7]

See also

• Transcription coregulator

Further reading

• Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR . TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity . Proceedings of the National Academy of Sciences of the United States of America . 104 . 11 . 4700–5 . Mar 2007 . 17360587 . 1838663 . 10.1073/pnas.0607524104 . 2007PNAS..104.4700K . free .
• Takemori H, Kajimura J, Okamoto M . TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain . The FEBS Journal . 274 . 13 . 3202–9 . Jul 2007 . 17565599 . 10.1111/j.1742-4658.2007.05889.x . 30323449 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 3 . 169–76 . Jun 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
• Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G . Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors . Experimental Cell Research . 292 . 1 . 21–8 . Jan 2004 . 14720503 . 10.1016/j.yexcr.2003.09.007 .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . Aug 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2004CBio...14.1436J . 2371325 .
• Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M . The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector . Cell . 119 . 1 . 61–74 . Oct 2004 . 15454081 . 10.1016/j.cell.2004.09.015 . 18616459 . free .
• Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, Chen CH, Song C, Garza D, Labow M . Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins . Current Biology . 14 . 23 . 2156–61 . Dec 2004 . 15589160 . 10.1016/j.cub.2004.11.002 . 5934014 . free . 2004CBio...14.2156B .
• Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G . Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion . Genes, Chromosomes & Cancer . 43 . 2 . 202–5 . Jun 2005 . 15729701 . 10.1002/gcc.20168 . 39267344 .
• Komiya T, Park Y, Modi S, Coxon AB, Oh H, Kaye FJ . Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation . Oncogene . 25 . 45 . 6128–32 . Oct 2006 . 16652146 . 10.1038/sj.onc.1209627 . 22409834 .
• Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY . TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats . Journal of Virology . 80 . 14 . 7052–9 . Jul 2006 . 16809310 . 1489057 . 10.1128/JVI.00103-06 .
• Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters LA, Nakamura H, Okamoto M . Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade . The FEBS Journal . 273 . 12 . 2730–48 . Jun 2006 . 16817901 . 10.1111/j.1742-4658.2006.05291.x . 44953050 . free .
• Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H . MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma . Clinical Cancer Research . 12 . 13 . 3902–7 . Jul 2006 . 16818685 . 10.1158/1078-0432.CCR-05-2376 . 17202179 .

Notes and References

1. Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ . t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway . Nature Genetics . 33 . 2 . 208–13 . Feb 2003 . 12539049 . 10.1038/ng1083 . 23417795 .
2. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M . TORCs: transducers of regulated CREB activity . Molecular Cell . 12 . 2 . 413–23 . Aug 2003 . 14536081 . 10.1016/j.molcel.2003.08.013 . free .
3. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA . Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells . Proceedings of the National Academy of Sciences of the United States of America . 100 . 21 . 12147–52 . Oct 2003 . 14506290 . 218727 . 10.1073/pnas.1932773100 . free .
4. Web site: Entrez Gene: CRTC1 CREB regulated transcription coactivator 1 .
5. Web site: CRTC1 (CREB regulated transcription coactivator 1) . Huret J-L . Atlas of Genetics and Cytogenetics in Oncology and Haematology . INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers .
6. Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR . TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity . Proceedings of the National Academy of Sciences of the United States of America . 104 . 11 . 4700–5 . Mar 2007 . 17360587 . 1838663 . 10.1073/pnas.0607524104 . 2007PNAS..104.4700K . free .
7. Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA . Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages . The Journal of Neuroscience . 34 . 17 . 5776–87 . Apr 2014 . 24760838 . 10.1523/JNEUROSCI.5288-13.2014 . 6608295 . free .