CP-532,903 explained

CP-532,903 is a selective adenosine A3 subtype receptor agonist. It has antiinflammatory effects and has been shown to reduce superoxide generation in damaged tissues,[1] and protects against tissue damage following myocardial ischemia,[2] mediated via an interaction with ATP-sensitive potassium channels.[3]

Notes and References

  1. 18583455 . 2008 . Van Der Hoeven . D. . Wan . T. C. . Auchampach . J. A. . Activation of the A(3) adenosine receptor suppresses superoxide production and chemotaxis of mouse bone marrow neutrophils . Molecular Pharmacology . 74 . 3 . 685–696 . 10.1124/mol.108.048066 . 2574951 .
  2. 12919933 . 2003 . Tracey . W. R. . Magee . W. P. . Oleynek . J. J. . Hill . R. J. . Smith . A. H. . Flynn . D. M. . Knight . D. R. . Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury . American Journal of Physiology. Heart and Circulatory Physiology . 285 . 6 . H2780-7 . 10.1152/ajpheart.00411.2003 .
  3. 10.1124/jpet.107.127480 . The A3 Adenosine Receptor Agonist CP-532,903 [ N 6-(2,5-Dichlorobenzyl)-3′-aminoadenosine-5′- N -methylcarboxamide] Protects against Myocardial Ischemia/Reperfusion Injury via the Sarcolemmal ATP-Sensitive Potassium Channel . 2008 . Wan . Tina C. . Ge . Zhi-Dong . Tampo . Akihito . Mio . Yasushi . Bienengraeber . Martin W. . Tracey . W. Ross . Gross . Garrett J. . Kwok . Wai-Meng . Auchampach . John A. . Journal of Pharmacology and Experimental Therapeutics . 324 . 234–243 . 17906066 . 2435594 .

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