CLIP1 explained

CAP-Gly domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.^[1]

Interactions

CLIP1 has been shown to interact with IQGAP1,^[2] Mammalian target of rapamycin^[3] and PAFAH1B1.^[4]

Further reading

• Galjart N . CLIPs and CLASPs and cellular dynamics . Nature Reviews Molecular Cell Biology . 6 . 6 . 487–98 . Jun 2005 . 15928712 . 10.1038/nrm1664 . 23216754 .
• Pierre P, Scheel J, Rickard JE, Kreis TE . CLIP-170 links endocytic vesicles to microtubules . Cell . 70 . 6 . 887–900 . Sep 1992 . 1356075 . 10.1016/0092-8674(92)90240-D . 41119165 .
• Bilbe G, Delabie J, Brüggen J, Richener H, Asselbergs FA, Cerletti N, Sorg C, Odink K, Tarcsay L, Wiesendanger W . Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease . The EMBO Journal . 11 . 6 . 2103–13 . Jun 1992 . 1600942 . 556677 . 10.1002/j.1460-2075.1992.tb05269.x.
• Pierre P, Pepperkok R, Kreis TE . Molecular characterization of two functional domains of CLIP-170 in vivo . Journal of Cell Science . 107 . 7 . 1909–20 . Jul 1994 . 10.1242/jcs.107.7.1909 . 7983157 .
• Hilliker C, Delabie J, Speleman F, Bilbe G, Bruggen J, Van Leuven F, Van den Berghe H . Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus . Cytogenetics and Cell Genetics . 65 . 3 . 172–6 . 1993 . 8222754 . 10.1159/000133625 .
• Griparic L, Keller TC . Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1405 . 1–3 . 35–46 . Oct 1998 . 9784600 . 10.1016/S0167-4889(98)00096-2 . free .
• Perez F, Diamantopoulos GS, Stalder R, Kreis TE . CLIP-170 highlights growing microtubule ends in vivo . Cell . 96 . 4 . 517–27 . Feb 1999 . 10052454 . 10.1016/S0092-8674(00)80656-X . 18082011 . free .
• Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N . Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts . Cell . 104 . 6 . 923–35 . Mar 2001 . 11290329 . 10.1016/S0092-8674(01)00288-4 . 14443149 . free .
• Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O . LIS1, CLIP-170's key to the dynein/dynactin pathway . Molecular and Cellular Biology . 22 . 9 . 3089–102 . May 2002 . 11940666 . 133759 . 10.1128/MCB.22.9.3089-3102.2002 .
• Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ . The cytoplasmic linker protein CLIP-170 is a human autoantigen . Clinical and Experimental Immunology . 127 . 3 . 533–8 . Mar 2002 . 11966772 . 1906301 . 10.1046/j.1365-2249.2002.01756.x .
• Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K . Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 . Cell . 109 . 7 . 873–85 . Jun 2002 . 12110184 . 10.1016/S0092-8674(02)00800-0 . 15158637 . free .
• Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF . The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase . EMBO Reports . 3 . 10 . 988–94 . Oct 2002 . 12231510 . 1307618 . 10.1093/embo-reports/kvf197 .
• Sahin U, Neumann F, Tureci O, Schmits R, Perez F, Pfreundschuh M . Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells . Blood . 100 . 12 . 4139–45 . Dec 2002 . 12433698 . 10.1182/blood.V100.12.4139 . free .
• Goodson HV, Skube SB, Stalder R, Valetti C, Kreis TE, Morrison EE, Schroer TA . CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms . Cell Motility and the Cytoskeleton . 55 . 3 . 156–73 . Jul 2003 . 12789661 . 10.1002/cm.10114 .
• Ho SM, Lau KM, Mok SC, Syed V . Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells . Oncogene . 22 . 27 . 4243–56 . Jul 2003 . 12833147 . 10.1038/sj.onc.1206437 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP . Phosphoproteomic analysis of the developing mouse brain . Molecular & Cellular Proteomics . 3 . 11 . 1093–101 . Nov 2004 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K . Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration . Developmental Cell . 7 . 6 . 871–83 . Dec 2004 . 15572129 . 10.1016/j.devcel.2004.10.017 . free .

Notes and References

1. Web site: Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1.
2. Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K . Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 . Cell . 109 . 7 . 873–85 . Jun 2002 . 12110184 . 10.1016/S0092-8674(02)00800-0 . 15158637 . free .
3. Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF . The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase . EMBO Reports . 3 . 10 . 988–94 . Oct 2002 . 12231510 . 1307618 . 10.1093/embo-reports/kvf197 .
4. Casper Hoogenraad. Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O . LIS1, CLIP-170's key to the dynein/dynactin pathway . Molecular and Cellular Biology . 22 . 9 . 3089–102 . May 2002 . 11940666 . 133759 . 10.1128/MCB.22.9.3089-3102.2002 .