CLDN19 explained

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene.^[1] It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.^{[2] [3]}

Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM]^[4]

Further reading

• Kniesel U, Wolburg H . Tight junctions of the blood-brain barrier . Cellular and Molecular Neurobiology . 20 . 1 . 57–76 . February 2000 . 10690502 . 10.1023/A:1006995910836 . 26473781 .
• Heiskala M, Peterson PA, Yang Y . The roles of claudin superfamily proteins in paracellular transport . Traffic . 2 . 2 . 93–98 . February 2001 . 11247307 . 10.1034/j.1600-0854.2001.020203.x . 12132159 .
• Tsukita S, Furuse M, Itoh M . Multifunctional strands in tight junctions . Nature Reviews. Molecular Cell Biology . 2 . 4 . 285–293 . April 2001 . 11283726 . 10.1038/35067088 . 36524601 .
• Tsukita S, Furuse M . Claudin-based barrier in simple and stratified cellular sheets . Current Opinion in Cell Biology . 14 . 5 . 531–536 . October 2002 . 12231346 . 10.1016/S0955-0674(02)00362-9 .
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE . Tight junction proteins . Progress in Biophysics and Molecular Biology . 81 . 1 . 1–44 . January 2003 . 12475568 . 10.1016/S0079-6107(02)00037-8 .
• Lee NP, Tong MK, Leung PP, Chan VW, Leung S, Tam PC, Chan KW, Lee KF, Yeung WS, Luk JM . Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease . FEBS Letters . 580 . 3 . 923–931 . February 2006 . 16427635 . 10.1016/j.febslet.2006.01.019 . 21297265 . free . 2006FEBSL.580..923L .
• Konrad M, Schaller A, Seelow D, Pandey AV, Waldegger S, Lesslauer A, Vitzthum H, Suzuki Y, Luk JM, Becker C, Schlingmann KP, Schmid M, Rodriguez-Soriano J, Ariceta G, Cano F, Enriquez R, Juppner H, Bakkaloglu SA, Hediger MA, Gallati S, Neuhauss SC, Nurnberg P, Weber S . Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement . American Journal of Human Genetics . 79 . 5 . 949–957 . November 2006 . 17033971 . 1698561 . 10.1086/508617 .
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS . Systems Proteomics View of the Endogenous Human Claudin Protein Family . Journal of Proteome Research . 15 . 2 . 339–359 . February 2016 . 26680015 . 4777318 . 10.1021/acs.jproteome.5b00769 .

Notes and References

1. Web site: Entrez Gene: CLDN19 claudin 19.
2. Naeem M, Hussain S, Akhtar N . Mutation in the tight-junction gene claudin 19 (CLDN19) and familial hypomagnesemia, hypercalciuria, nephrocalcinosis (FHHNC) and severe ocular disease . American Journal of Nephrology . 34 . 3 . 241–248 . 2011 . 21791920 . 10.1159/000330854 . free .
3. Konrad M, Schaller A, Seelow D, Pandey AV, Waldegger S, Lesslauer A, Vitzthum H, Suzuki Y, Luk JM, Becker C, Schlingmann KP, Schmid M, Rodriguez-Soriano J, Ariceta G, Cano F, Enriquez R, Juppner H, Bakkaloglu SA, Hediger MA, Gallati S, Neuhauss SC, Nurnberg P, Weber S . Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement . American Journal of Human Genetics . 79 . 5 . 949–957 . November 2006 . 17033971 . 1698561 . 10.1086/508617 .
4. Web site: Entrez Gene: CLDN19 claudin 19.