CEP57 explained

Centrosomal protein of 57 kDa is a protein that in humans is encoded by the CEP57 gene.^{[1] [2]} It is also known as translokin.

Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003).[supplied by OMIM]^[3]

External links

• • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 57 kDa

Further reading

• Hoja MR, Wahlestedt C, Höög C . A visual intracellular classification strategy for uncharacterized human proteins. . Exp. Cell Res. . 259 . 1 . 239–46 . 2000 . 10942595 . 10.1006/excr.2000.4948 .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Bossard C, Laurell H, Van den Berghe L . Translokin is an intracellular mediator of FGF-2 trafficking. . Nat. Cell Biol. . 5 . 5 . 433–9 . 2003 . 12717444 . 10.1038/ncb979 . 21792653 . etal.
• Kim YS, Nakanishi G, Oudes AJ . Tsp57: a novel gene induced during a specific stage of spermatogenesis. . Biol. Reprod. . 70 . 1 . 106–13 . 2004 . 12954732 . 10.1095/biolreprod.103.018465 . etal. free .
• Andersen JS, Wilkinson CJ, Mayor T . Proteomic characterization of the human centrosome by protein correlation profiling. . Nature . 426 . 6966 . 570–4 . 2003 . 14654843 . 10.1038/nature02166 . 2003Natur.426..570A . 4427303 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ahn J, Chung KS, Kim DU . Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. . J. Biochem. Mol. Biol. . 37 . 6 . 741–8 . 2005 . 15607035 . 10.5483/bmbrep.2004.37.6.741. etal. free .

Notes and References

1. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H . Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res . 2 . 1 . 37–43 . Jul 1995 . 7788527 . 10.1093/dnares/2.1.37 . etal. free .
2. Web site: Entrez Gene: CEP57 centrosomal protein 57kDa.
3. Web site: Entrez Gene: CEP57 centrosomal protein 57kDa.