CEP192 explained

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.^{[1] [2]} It is the homolog of the C. elegans and D. melanogaster gene SPD-2.^[3]

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells.^[3] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.^[4]

Further reading

• Nagase T, Kikuno R, Nakayama M . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 4 . 273–81 . 2000 . 10997877 . 10.1093/dnares/7.4.271. etal. free .
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA . Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function . J. Cell Biol. . 129 . 6 . 1617–28 . 1995 . 7790358 . 2291169 . 10.1083/jcb.129.6.1617 .
• Zhu F, Lawo S, Bird A . The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis . Curr. Biol. . 18 . 2 . 136–41 . 2008 . 18207742 . 10.1016/j.cub.2007.12.055 . 16159409 . etal. free . 2008CBio...18..136Z .
• Gomez-Ferreria MA, Rath U, Buster DW . Human Cep192 is required for mitotic centrosome and spindle assembly . Curr. Biol. . 17 . 22 . 1960–6 . 2007 . 17980596 . 10.1016/j.cub.2007.10.019 . 10245690 . etal. free . 2007CBio...17.1960G .
• Mayor T, Stierhof YD, Tanaka K . The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion . J. Cell Biol. . 151 . 4 . 837–46 . 2000 . 11076968 . 2169446 . 10.1083/jcb.151.4.837 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 . etal.
• Wiemann S, Weil B, Wellenreuther R . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R . etal.
• Sowa ME, Bennett EJ, Gygi SP, Harper JW . Defining the Human Deubiquitinating Enzyme Interaction Landscape . Cell . 138 . 2 . 389–403 . 2009 . 19615732 . 2716422 . 10.1016/j.cell.2009.04.042 .
• Takahashi M, Yamagiwa A, Nishimura T . Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex . Mol. Biol. Cell . 13 . 9 . 3235–45 . 2002 . 12221128 . 124155 . 10.1091/mbc.E02-02-0112 . etal.
• Casenghi M, Meraldi P, Weinhart U . Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation . Dev. Cell . 5 . 1 . 113–25 . 2003 . 12852856 . 10.1016/S1534-5807(03)00193-X . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Petretti C, Savoian M, Montembault E . The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation . EMBO Rep. . 7 . 4 . 418–24 . 2006 . 16462731 . 1456919 . 10.1038/sj.embor.7400639 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Pope SN, Lee IR . Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin . J. Steroid Biochem. Mol. Biol. . 94 . 1–3 . 203–8 . 2005 . 15862967 . 10.1016/j.jsbmb.2005.01.007 . 9746088 .

Notes and References

1. Web site: Entrez Gene: centrosomal protein 192kDa.
2. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M . Proteomic characterization of the human centrosome by protein correlation profiling . Nature . 426 . 6966 . 570–4 . December 2003 . 14654843 . 10.1038/nature02166 . 2003Natur.426..570A . 4427303 .
3. 10.1016/j.cub.2007.12.055. 18207742. 2008. Zhu . F.. Lawo . S.. Bird . A.. Pinchev . D.. Ralph . A.. Richter . C.. Müller-Reichert . T.. Kittler . R.. Hyman . A.. Pelletier . L.. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. 18. 2. 136–141. Current Biology. 16159409. free. 2008CBio...18..136Z.
4. 10.1016/j.cub.2007.10.019. 17980596. 2007. Gomez-Ferreria . M.. Rath . U.. Buster . D.. Chanda . S.. Caldwell . J.. Rines . D.. Sharp . D.. Human Cep192 is required for mitotic centrosome and spindle assembly. 17. 22. 1960–1966. Current Biology. 10245690. free. 2007CBio...17.1960G.