CEP170 explained

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.^{[1] [2]}

Function

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 (Cdk1) and polo-like kinase 1 (PLK1), and functions in maintaining microtubule organization, cell morphology and cilium stability.^[1]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.^[1]

External links

• • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 170 kDa (CEP170)

Further reading

• Andersen JS, Wilkinson CJ, Mayor T . Proteomic characterization of the human centrosome by protein correlation profiling. . Nature . 426 . 6966 . 570–4 . 2003 . 14654843 . 10.1038/nature02166 . 2003Natur.426..570A . 4427303 . etal.
• Jin J, Smith FD, Stark C . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . etal. free . 2004CBio...14.1436J .
• Guarguaglini G, Duncan PI, Stierhof YD . The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. . Mol. Biol. Cell . 16 . 3 . 1095–107 . 2005 . 15616186 . 10.1091/mbc.E04-10-0939 . 551476 . etal.
• Kim JE, Tannenbaum SR, White FM . Global phosphoproteome of HT-29 human colon adenocarcinoma cells. . J. Proteome Res. . 4 . 4 . 1339–46 . 2005 . 16083285 . 10.1021/pr050048h .
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Lamla S . Functional characterisation of the centrosomal protein Cep170. . Dissertation, LMU Muenchen: Fakultät für Biologie. 2009 . Text.PhDThesis . URN nbn:de:bvb:19-97838 .

Notes and References

1. Web site: Entrez Gene: CEP170 centrosomal protein 170kDa.
2. Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA . The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles . Molecular Biology of the Cell . 16 . 3 . 1095–107 . March 2005 . 15616186 . 551476 . 10.1091/mbc.E04-10-0939 .