CEP120 explained
Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.[1] [2]
Function
This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects.[1]
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 120 kDa (CEP120)
Further reading
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
- Vasan RS, Glazer NL, Felix JF . Genetic Variants Associated With Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data . JAMA . 302 . 2 . 168–78 . 2009 . 19584346 . 2975567 . 10.1001/jama.2009.978-a . etal.
- Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 . etal.
- Guerrier S, Polleux F . The ups and downs of neural progenitors: Cep120 and TACCs control interkinetic nuclear migration . Neuron . 56 . 1 . 1–3 . 2007 . 17920006 . 10.1016/j.neuron.2007.09.019 . 14965494 . free .
- Thorleifsson G, Walters GB, Gudbjartsson DF . Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity . Nat. Genet. . 41 . 1 . 18–24 . 2009 . 19079260 . 10.1038/ng.274 . 764409 . etal.
Notes and References
- Web site: Entrez Gene: centrosomal protein 120kDa.
- Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH . Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool . Neuron . 56 . 1 . 79–93 . October 2007 . 17920017 . 2642594 . 10.1016/j.neuron.2007.08.026 .
