CDH16 explained

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.^{[1] [2] [3]}

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Thomson RB, Aronson PS . Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney. . Am. J. Physiol. . 277 . 1 Pt 2 . F146–56 . 1999 . 10409308 . 10.1152/ajprenal.1999.277.1.F146.
• Baudry D, Jeanpierre C . Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping. . Cytogenet. Cell Genet. . 88 . 3–4 . 253–4 . 2000 . 10828602 . 10.1159/000015531 . 83989085 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Thomson RB, Mentone S, Kim R . Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. . Am. J. Physiol. Renal Physiol. . 285 . 5 . F870–80 . 2003 . 12851251 . 10.1152/ajprenal.00153.2003 . etal.
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Wendeler MW, Praus M, Jung R . Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. . Exp. Cell Res. . 294 . 2 . 345–55 . 2004 . 15023525 . 10.1016/j.yexcr.2003.11.022 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Hishikawa K, Marumo T, Miura S . Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. . Biochem. Biophys. Res. Commun. . 328 . 1 . 288–91 . 2005 . 15670782 . 10.1016/j.bbrc.2004.12.167 . etal.
• Thedieck C, Kuczyk M, Klingel K . Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. . Br. J. Cancer . 92 . 11 . 2010–7 . 2005 . 15886705 . 10.1038/sj.bjc.6602597 . 2361784 . etal.
• Kuehn A, Paner GP, Skinnider BF . Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. . Am. J. Surg. Pathol. . 31 . 10 . 1528–33 . 2007 . 17895753 . 10.1097/PAS.0b013e318058818c . 46401984 . etal.

Notes and References

1. Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS . cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin . Genomics . 51 . 3 . 445–51 . Oct 1998 . 9721215 . 10.1006/geno.1998.5402 . free .
2. Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS . Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family . J Biol Chem . 270 . 29 . 17594–601 . Aug 1995 . 7615566 . 10.1074/jbc.270.29.17594 . free .
3. Web site: Entrez Gene: CDH16 cadherin 16, KSP-cadherin.
4. Web site: Entrez Gene: CDH16 cadherin 16, KSP-cadherin.