CCT6B explained

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.^{[1] [2] [3]}

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Further reading

• Stirling PC, Cuéllar J, Alfaro GA . PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates . J. Biol. Chem. . 281 . 11 . 7012–21 . 2006 . 16415341 . 10.1074/jbc.M513235200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Suzuki Y, Yamashita R, Shirota M . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Ozaki K, Kuroki T, Hayashi S, Nakamura Y . Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method . Genomics . 36 . 2 . 316–9 . Jan 1997 . 8812458 . 10.1006/geno.1996.0467 .
2. Kubota H, Hynes GM, Kerr SM, Willison KR . Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1 . FEBS Lett . 402 . 1 . 53–6 . Feb 1997 . 9013858 . 10.1016/S0014-5793(96)01501-3 . 1972107 . free .
3. Web site: Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2).