CCNI (gene) explained

Cyclin-I is a protein that in humans is encoded by the CCNI gene.^{[1] [2]}

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined.

Further reading

• Sun ZL, Zhu Y, Wang FQ . Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers . Biochim. Biophys. Acta . 1774 . 6 . 764–71 . 2007 . 17507299 . 10.1016/j.bbapap.2007.04.001 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Zhu X, Naz RK . Expression of a novel isoform of cyclin I in human testis . Biochem. Biophys. Res. Commun. . 249 . 1 . 56–60 . 1998 . 9705831 . 10.1006/bbrc.1998.9052 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Nakamura T, Sanokawa R, Sasaki YF, Ayusawa D, Oishi M, Mori N . Cyclin I: a new cyclin encoded by a gene isolated from human brain . Exp Cell Res . 221 . 2 . 534–42 . Jan 1996 . 7493655 . 10.1006/excr.1995.1406 .
2. Web site: Entrez Gene: CCNI cyclin I.