CCNG2 explained

Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene.^{[1] [2]}

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.

Interactions

CCNG2 has been shown to interact with PPP2CA.^[3]

Further reading

• Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF . Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression . J. Biol. Chem. . 271 . 11 . 6050–61 . 1996 . 8626390 . 10.1074/jbc.271.11.6050 . free .
• Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC . Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest . J. Biol. Chem. . 277 . 30 . 27449–67 . 2002 . 11956189 . 10.1074/jbc.M111693200 . free .
• Tian YL, Liu FR, Liu J, Jiang L, Luo Y, Zhang X . [Ectopic expression of cyclin G2 inhibits cell proliferation in HeLa cancer cell line] . AI Zheng . 21 . 6 . 577–81 . 2002 . 12452053 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Bergqvist M, Brattström D, Brodin D, Lindkvist A, Dahlman-Wright K, Dreilich M, Wagenius G, Paulsson-Karlsson Y . Genes associated with telomerase activity levels in esophageal carcinoma cell lines . Diseases of the Esophagus . 19 . 1 . 20–3 . 2006 . 16364039 . 10.1111/j.1442-2050.2006.00532.x . free .
• Stossi F, Likhite VS, Katzenellenbogen JA, Katzenellenbogen BS . Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter . J. Biol. Chem. . 281 . 24 . 16272–8 . 2006 . 16608856 . 10.1074/jbc.M513405200 . free .
• Arachchige Don AS, Dallapiazza RF, Bennin DA, Brake T, Cowan CE, Horne MC . Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest . Exp. Cell Res. . 312 . 20 . 4181–204 . 2006 . 17123511 . 1862360 . 10.1016/j.yexcr.2006.09.023 .

Notes and References

1. Bates S, Rowan S, Vousden KH . Characterisation of human cyclin G1 and G2: DNA damage inducible genes . Oncogene . 13 . 5 . 1103–9 . Nov 1996 . 8806701 .
2. Web site: Entrez Gene: CCNG2 cyclin G2.
3. Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC . Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest . J. Biol. Chem. . 277 . 30 . 27449–67 . Jul 2002 . 11956189 . 10.1074/jbc.M111693200 . free .