CABIN1 explained

Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene.^{[1] [2] [3]}

Function

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.

Interactions

CABIN1 has been shown to interact with:

• Amphiphysin,^[4]
• MEF2B,^{[5] [6]}
• MEF2D,^{[6] [7]} and
• SIN3A.^[7]

Further reading

• Liu JO . Endogenous protein inhibitors of calcineurin . Biochemical and Biophysical Research Communications . 311 . 4 . 1103–9 . Nov 2003 . 14623296 . 10.1016/j.bbrc.2003.10.020 .
• Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN . Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression . Cell . 89 . 3 . 349–56 . May 1997 . 9150134 . 10.1016/S0092-8674(00)80215-9 . free .
• Youn HD, Sun L, Prywes R, Liu JO . Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 . Science . 286 . 5440 . 790–3 . Oct 1999 . 10531067 . 10.1126/science.286.5440.790 .
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . Dec 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Youn HD, Grozinger CM, Liu JO . Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4 . The Journal of Biological Chemistry . 275 . 29 . 22563–7 . Jul 2000 . 10825153 . 10.1074/jbc.C000304200 . free .
• Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH . The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis . The Journal of Biological Chemistry . 275 . 44 . 34017–20 . Nov 2000 . 10931822 . 10.1074/jbc.C000429200 . free .
• Youn HD, Liu JO . Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 . Immunity . 13 . 1 . 85–94 . Jul 2000 . 10933397 . 10.1016/S1074-7613(00)00010-8 . free .
• Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J . Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells . The Journal of Experimental Medicine . 194 . 10 . 1449–59 . Nov 2001 . 11714752 . 2193671 . 10.1084/jem.194.10.1449 .
• Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L . Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 . Nature . 422 . 6933 . 730–4 . Apr 2003 . 12700764 . 10.1038/nature01555 . 2003Natur.422..730H . 4430658 .
• Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y . Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis . Cell . 116 . 1 . 51–61 . Jan 2004 . 14718166 . 10.1016/S0092-8674(03)01064-X . free .
• Rodríguez A, Martínez-Martínez S, López-Maderuelo MD, Ortega-Pérez I, Redondo JM . The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT . The Journal of Biological Chemistry . 280 . 11 . 9980–4 . Mar 2005 . 15671033 . 10.1074/jbc.C400401200 . free .
• Li XN, Li YL, Liu GB, Ding YQ . Selection of choriocarcinoma-associated genes using bioinformatics . Di 1 Jun Yi da Xue Xue Bao = Academic Journal of the First Medical College of PLA . 25 . 1 . 1–6 . Jan 2005 . 15683985 .
• Pan F, Means AR, Liu JO . Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation . The EMBO Journal . 24 . 12 . 2104–13 . Jun 2005 . 15902271 . 1150881 . 10.1038/sj.emboj.7600685 .
• Jang H, Cho EJ, Youn HD . A new calcineurin inhibition domain in Cabin1 . Biochemical and Biophysical Research Communications . 359 . 1 . 129–35 . Jul 2007 . 17531200 . 10.1016/j.bbrc.2007.05.066 .

Notes and References

1. Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO . Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes . Immunity . 8 . 6 . 703–11 . Jun 1998 . 9655484 . 10.1016/S1074-7613(00)80575-0 . free .
2. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 4 . 2 . 141–50 . Apr 1997 . 9205841 . 10.1093/dnares/4.2.141 . free .
3. Web site: Entrez Gene: CABIN1 calcineurin binding protein 1.
4. Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH . The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis . The Journal of Biological Chemistry . 275 . 44 . 34017–20 . Nov 2000 . 10931822 . 10.1074/jbc.C000429200 . free .
5. Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L . Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 . Nature . 422 . 6933 . 730–4 . Apr 2003 . 12700764 . 10.1038/nature01555 . 2003Natur.422..730H . 4430658 .
6. Youn HD, Sun L, Prywes R, Liu JO . Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 . Science . 286 . 5440 . 790–3 . Oct 1999 . 10531067 . 10.1126/science.286.5440.790.
7. Youn HD, Liu JO . Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 . Immunity . 13 . 1 . 85–94 . Jul 2000 . 10933397 . 10.1016/s1074-7613(00)00010-8. free .