| Bolshoy Salym | |
| Mouth: | Ob |
| Mouth Coordinates: | 61.0969°N 70.9018°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Russia |
| Length Km: | 583 |
| Basin Size Km2: | 18100 |
The Bolshoy Salym is a river in Khanty-Mansi Autonomous Okrug, Russia. It is a left tributary of the Ob. It is long, and has a drainage basin of .