Bisulepin Explained

Bisulepin is strong and relatively selective antihistamine (H₁ antagonist) with hypnotic, antiadrenergic and very weak anticholinergic and antiserotonergic effects. Bisulepin is marketed in the Czech Republic and Slovakia under the trademark Dithiaden as tablets and injections.

The registered active form is the trans- (i.e. E-) isomer.^{[1] [2]}

Oxidation of the sulfur bridge gave rise to a compound that is called Dithiadenoxide.

See also

• Dosulepin
• Doxepin

References

1. Polívka Z, Rajšner M, Metyš J, Holubek J, Svátek E, Ryska M, Protiva M . Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds . Collection of Czechoslovak Chemical Communications . 1983 . 48 . 2 . 623–641 . 10.1135/cccc19830623.
2. Pharmacopoea Bohemoslovenica 4 (1987), vol. 2, p. 132 states that Bisulepinium chloratum (bisulepinium chloride) is trans-[3-(4,9-dihydro-thieno[2,3-''c''][2]benzithiepin-4-yliden)propyl]dimethylamoniumchlorid (Czech). The cis- isomer is considered as an impurity, max. amount 2.0 %.

External links

• Chemical data for bisulepin hydrochloride