| Bill Thompson | |
| State House: | South Dakota |
| State: | South Dakota |
| District: | 13th |
| Term Start: | 2003 |
| Term End: | 2010 |
| Preceded: | Don Hennies |
| Party: | Democrat |
| Birth Date: | 14 May 1949 |
| Birth Place: | Aberdeen, South Dakota |
| Spouse: | Anne |
| Children: | Sarah |
| Alma Mater: | Northern State University, University of Kansas |
| Profession: | educator |
| Residence: | Sioux Falls, South Dakota |
William R. Thompson (born May 14, 1949) is an American politician from South Dakota. A member of the Democratic Party, he served in the South Dakota House of Representatives from 2003 to 2010.