right|thumb|300px|Big Sandy Creek, Wyoming
The Big Sandy River (also called Big Sandy Creek) is a 141adj=midNaNadj=mid[1] tributary of the Green River in Wyoming in the United States.
It rises in eastern Sublette County, on the west side of the continental divide in the southern Wind River Range, in the Bridger Wilderness Area of the Bridger-Teton National Forest.
It flows south, southwest, southeast, then southwest, past the town of Farson and joins the Green in western Sweetwater County.
Above Farson, it is dammed to form the Big Sandy Reservoir.