BTMPS explained

BTMPS (also known as Tinuvin 770) is a hindered amine light stabilizer with the chemical formula . It is a white crystalline powder.[1]

In 2024 it was detected as an adulterant in illicitly sold fentanyl in the United States.[2] [3]

Production and reactions

Its production involves sebacic acid and tetramethylpiperidinol.[4]

Potential medical significance

It is capable of inhibiting nicotinic acetylcholine receptors.[5] Additionally, it is a potent blocker of L-type calcium channels.[6] [7] It is also able to induce dose-dependent hemodynamic alterations.[8] Similar to early calcium channel blockers, it can precipitate adrenergic release.[9]

Notes and References

  1. Web site: Bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate . pubchem.ncbi.nlm.nih.gov . en . 2024-09-20 . 2024-09-20 . https://web.archive.org/web/20240920123046/https://pubchem.ncbi.nlm.nih.gov/compound/Bis_2_2_6_6-tetramethyl-4-piperidyl_-sebacate . live .
  2. Web site: BTMPS . The Center for Forensic Science Research & Education.
  3. Web site: An industrial chemical is showing up in fentanyl in the U.S., troubling scientists . limited . Alpert Reyes . Emily . 16 September 2024 . Los Angeles Times . live . https://web.archive.org/web/20240916183931/https://www.latimes.com/california/story/2024-09-16/an-industrial-chemical-is-being-mixed-with-fentanyl#expand . 16 September 2024.
  4. Web site: Preparation method of hindered amine light stabilizer 770 . 13 August 2014 . 20 September 2024 . 20 September 2024 . https://web.archive.org/web/20240920123046/https://patents.google.com/patent/CN103980185A/en . live .
  5. Papke . RL . Craig . AG . Heinemann . SF . Inhibition of nicotinic acetylcholine receptors by bis (2,2,6,6-tetramethyl- 4-piperidinyl) sebacate (Tinuvin 770), an additive to medical plastics. . The Journal of Pharmacology and Experimental Therapeutics . February 1994 . 268 . 2 . 718–26 . 8113983.
  6. Glossmann . H . Hering . S . Savchenko . A . Berger . W . Friedrich . K . Garcia . ML . Goetz . MA . Liesch . JM . Zink . DL . Kaczorowski . GJ . A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker. . Proceedings of the National Academy of Sciences of the United States of America . 15 October 1993 . 90 . 20 . 9523–7 . 10.1073/pnas.90.20.9523 . free . 8415734. 47601 .
  7. Sótonyi . P . Keller . E . Járay . J . Nemes . B . Benkõ . T . Kovács . A . Tolokán . A . Rajs . I . A light stabilizer Tinuvin 770-induced toxic injury of adult rat cardiac myocytes. . Forensic Science International . 15 July 2001 . 119 . 3 . 322–7 . 10.1016/s0379-0738(00)00462-x . 11390147.
  8. Krepuska . M . Hubay . M . Zima . E . Kovacs . A . Kekesi . V . Kalasz . H . Szilagyi . B . Merkely . B . Sotonyi . P . Hemodynamic Effects of the Light Stabilizer Tinuvin 770 in Dogs In Vivo. . The Open Medicinal Chemistry Journal . 2018 . 12 . 88–97 . 10.2174/1874104501812010088 . 30288180. 6142673 .
  9. Sótonyi . P . Merkely . B . Hubay . M . Járay . J . Zima . E . Soós . P . Kovács . A . Szentmáriay . I . Comparative study on cardiotoxic effect of Tinuvin 770: a light stabilizer of medical plastics in rat model. . Toxicological Sciences . February 2004 . 77 . 2 . 368–74 . 10.1093/toxsci/kfh025 . 14657520.

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